CONFERENCE PUBLICATIONS AND PRESENTATIONS
 
2016
  • I. Tworowska, K. Ershadi, T. Vergote, G. Philippart, and J-L Morelle, Automated Radiosynthesis of 203Pb-SPECT agents for image guided TAT using TRASIS MINIAIO® synthesizer (SMARTMEDIX TM). J Nucl Med., 2016 57:279
  • T. Vergote, I. Tworowska, K. Ershadi, G. Philippart, and J-L Morelle, Radiosynthesis of 68Ga-PSMA-HBEDcc using Trasis MiniAIO synthesizer. J Nucl Med.,  2016 57:1102
  • I. Tworowska, N. Wagh, M. Li, S. Thamake, E. Delpassand, and M. Schultz, In vivo validation of a Pb203-SPECT imaging probe for image-guided alpha particle therapy for metastatic melanoma. J Nucl Med., 2016 57:42
  • Tworowska I., Erhadi K.; Vergote T., Morelle J-L, Philippart G., Synthesis of 203Pb- SPECT conjugates for image guided TAT using Trasis miniAIO® Module(SmartMedixTM). Mol Imaing and Biol., 18, 2 S, 2016
  • Wagh, N., Li M, Thamake S., Delpassand E.,, Schultz M., Tworowska I. Development of Pb203-SPECT imaging probes for image guided targeted alpha particle therapy of metastatic melanoma. Wagh, N., Li M, Thamake S., Delpassand E., Schultz M., Tworowska I., Mol Imaing and Biol., 18, 2 S, 2016
  • N. Wagh, S. Thamake, M.  Li, D. Ranganathan, M. Schultz, E. S. Delpassand, I. Tworowska, Validation Studies of Theranostic Glycoconjugates in Metastatic Melanoma WJNM 2016 11, v.15 | Issue 4 (Supplement)
2015
  • I. Tworowska, N. Wagh, S. Thamake, J. Reedy, D. Ranganathan, I. Goldman, M. Brechbiel, M. Schultz, and E. Delpassand, Pb203-labeled radiotracers targeting metastatic melanoma - Optimization of labeling of DOTA- and TCMC-conjugates. J. Nucl. Med. 2015 56:1061.
  • E. Delpassand, H. Mohammadali, S. Thamake, S. Broline, D. Ranganathan, N. Wagh, I. Tworowska, A. Delpassand, J. Puentes, 177Lutetium-DOTA-Octreotate Therapy in Progressive Somatostatin Receptor-Expressing Neuroendocrine Neoplasms J. Nucl. Med. 2015 56: 6.
  • D. Ranganathan, N. Wagh, S. Thamake, I. Tworowska, J. Puente, A. Delpassand, E. Delpassand, Development of GalioMedix kit to prepare 68Ga-DOTATATE injection solution for PET imaging of neuroendocrine tumors. J. Nucl. Med., 2015 56: 19.
  • I. Tworowska, M. Schultz, D. Ranganathan, S. Thamake, E. Delpassand, K. Zhernosekov, S. Marx, Characterization of 68Ge/68Ga ITG GmbH generators and their long term validation. J. Nucl. Med., 2015, 56: 24.
  • N. Wagh, S. Thamake , J. Reedy , D. Ranganathan , E. Delpassand , M. K. Schultz, I. Tworowska, Biological evaluation of Ga68-labeled click-conjugate for targeting of metastatic melanoma. J. Nucl. Med., 2015, 56:29.
  • E. Delpassand, S. Broline, R. Amerinia, S. Thamake, D. Ranganathan, N. Wagh, I. Tworowska, Side by side comparison of the performance of 68Ga-DOTATATE PET/CT and 111In-DTPA-Octreotide SPECT in Patients with Somatostatin expressing Neuroendocrine Tumors J. Nucl. Med., 2015 56:2A-6.
2014
  • I. Tworowska, S. Kapoor, K. Kloepping, E. Delpassand, M. Schultz, Molecular imaging of metastatic melanoma using Ga-68 GLUT1 targeted glucosamines. J. Nucl. Med. May 2014 55:1045.
  • A. Mojtahedi, S. Thamake, R. Amerinia, I. Tworowska, D. Ranganathan, and E. Delpassand, Assessment of vulnerable atherosclerotic and fibrotic plaques in coronary arteries using 68Ga-DOTATATE PET/CT. J. Nucl. Med. May 2014 55:1776
  • D. Ranganathan, S. Thamake, I. Tworowska, and E. Delpassand, Chelator based glucosamine derivative for Ga-68 based diagnostic PET imaging of malignant tumors. J. Nucl. Med. May 2014 55:1004
  • M. Kumar, S. Broline, R. Amerinia, S. Thamake, D. Ranganathan, I. Tworowska, and E. Delpassand, Comparison of sensitivity of 68Ga-DOTATATE PET/CT and 111In-Octreotide SPECT in somatostatin positive neuroendocrine tumors. J. Nucl. Med. May 2014 55:559
2013
  • I. Tworowska, D. Ranganathan, S. Thamake, and E. Delpassand., Evaluation of organic matrix-based 68Ge/68Ga generators for labeling of research and clinical-grade agents J. Nucl. Med., 2013, 54: 1202.
  • I. Tworowska, Y. Mackeyev, S. Thamake, D. Ranganathan, L. Wilson, and E. Delpassand., Functionalization of ultra-short carbon nanotubes with SC-11 targeting ligand, J. Nucl. Med., 2013, 54: 450.
  • S. Thamake, D. Ranganathan, I. Tworowska, and E. Delpassand, In vivo validation of novel GLUT-1 targeting click-conjugates, J. Nucl. Med., 2013,  54: 1081
  • "Radiopharmecuticals - from chemical design to clinical applications", invited talk, ACS-GHS, April 10th,  Houston TX
2012
  • Tworowska I.,  Zamanian S.,  Delpassand E., and Schultz M. , 68Ga-labeled click conjugate targeting GLUT1-transporters,  J. Nucl.  Med. 2012; 53,  1568.
  • Tworowska I., Ray S., Zamanian S., Delpassand E., Mackeyev Y., Wilson L., and Pomper M., 68Ga-labeled PSMA-targeting carbon nanotubes, J. Nucl. Med., 2012; 53: 1569
  • Tworowska I., Zamanian S., and Delpassand E., Characterization of organic matrix-based 68Ge/68Ga generators, J. Nucl. Med. 2012; 53: 1474.
  • “Targeting metabolic pathways in cancer cells using genistein derivatives”, Annual Congress of the European Association of Nuclear Medicine, Milano, Italy, October 27th-31st, , I. Tworowska, S. Zamanian, S. Thamake, E. S. Delpassand (poster)
  • “Targeting metabolic pathways in cancer cells”, CHI Conference Discovery on Target, Boston, MA, October 1-3rd, ,  I. Tworowska, S. Thamake, D. Ranganathan, E. S. Delpassand (poster).

 2011

  • I.Tworowska, J. Sims-Mourtada, D.Yang, F. Mourtada, E. Delpassand, Y. Mackeyev, L. Wilson, Carbon nanotubes modified with sonic-hedgehog ligand, J Nucl. Med., 2011, 52 (Supplement 1): 1479.
  • I. Tworowska, J. Sims-Mourtada, E. Delpassand, Application of click chemistry in the synthesis of 68Ga-labeled agents, J. Nucl. Med., 2011, 52 (Supplement 1): 1528.
  • R. Sharif, J. Sims-Mourtada, I. Tworowska, E. Delpassand, Survival of patients with disseminated neuroendocrine tumors following multiple cycles of high activity 111In pentetreotide: Can pretreatment FDG status be a predictive factor?, J. Nucl. Med.,2011, 52 (Supplement 1): 1312.
2010
  • Molecular Imaging Probes- The inside story, IBB NIH Biotech seminar Rice University,  Houston, December 1st
  • I. Tworowska, E. Delpassand, F. Mourtada, S. Ray, M. Pomper, and J. Sims-Mourtada, Hedgehog derivatives for tumor imaging;  J Nucl Med., 2010; 51 (Supplement 2): 484.
  • I.Tworowska, J. Sims-Mourtada, E. S. Delpassand, Bungoo Y., Pagel M., One-pot radiolabeling and purification of tracers on solid-phase,  J Nucl Med. 2010; 51 (Supplement 2):376  
  •  I. Tworowska, J. (Jim) Simon, J. Sims-Mourtada, F. Mourtada, and E. Delpassand, Automated manufacturing of clinical-grade 177Lu- labeling DOTA0-Tyr3-octreotate using SmarTrace, J Nucl Med. 2010; 51(Supplement 2): 1551.
  •  R. Sharif, J. Sims-Mourtada, I. Tworowska, and E. Delpassand, Long-term evaluation of renal toxicity with multiple doses of high activity 111-In-pentetreotide in patients with disseminated neuroendocrine tumors, J Nucl Med.,  2010; 51(Supplement 2): 1158.
  • E. S. Delpassand, R. Sharif, J. Sims-Mourtada, I. Tworowska, L. B. Anthony, Long-term survival and toxicity profile of patients with disseminated neuroendocrine tumors following multiple cycles of high activity 111In pentetreotide therapy, J Clin Oncol 28, 2010 (suppl; abstr e13545)
  • Radiolabeled Sonic Hedgehog as a ligand targeting cancer stem cells, Izabela Tworowska , Jennifer Sims-Mourtada, ACS      National Meeting, Boston MA, August 22-26th, presentation selected for recording.
  •  Synthesis of new radiopharmaceuticals for PET imaging by "click chemistry", J. Sims-Mourtada, I. Tworowska, ACS National   Meeting, Boston MA, August 22-26th
  • Nanotubes as radiopharmaceuticals for cancer imaging and therapy, Yuri Mackeyev, Jennifer Sims-Mourtada, Lon J. Wilson, Izabela Tworowska, ACS National Meeting,Boston MA, August 22-26th
  • Nanotubes as mutli-modality vehicles for imaging and therapy of cancer, Y. MacKeyev, J.Sims-Mourtada,  E. S. Delpassand,  L. Wilson, I. Tworowska, 5th European Molecular Imaging  Meeting – EMIM 2010, May 26-29th
  • Targeting cancer stem cells using radiolabeled Sonic Hedgehog, I. Tworowska,  E. S. Delpassand, J. Sims-Mourtada, 5th European Molecular Imaging  Meeting – EMIM 2010, May 26-29th
  • Imaging of cancer stem cells with radiolabeled Hedgehog,  I.Tworowska, J. Li,  F. Mourtada, W. Woodward, J. Sims-Mourtada
    American Association for Cancer Research Annual Meeting, Washington DC, April 17th-21st, (poster presentation, selected for the AACR press-release)
2009
  • I. Tworowska, H. Saso, J. Sims-Mourtada, F. Mourtada, E. Delpassand and A.Azhdarinia, 68Ga-glucosamine analogs for PET imaging of cancer, J Nucl Med. 2009; (50) 376 
  • 68Ga-glucosamine analogs for PET imaging of cancer, I.Tworowska, H.Saso, J.Sims-Mourtada, A. Azhdarinia, Society  of Nuclear Medicine Annual Meeting, Toronto Canada, June 13th-17th,  (oral presentation)
  • Synthesis and properties of 68Ga-MPC-glucosamine conjugates for PET imaging of cancer, I.Tworowska, H.Saso, J.Sims-Mourtada, A. Azhdarinia, 238th ACS National Meeting, Washington DC, August 16th-20th (oral presentation)
2008
  • Radiolabeled Sonic Hedgehog Protein as a Novel PET Imaging Agent, I. Tworowska, J. Sims-Mourtada, H. Saso, A. Azhdarinia, ACS 64th Southwest Regional Meeting (SWRM),  October 1st –4th, 
  • Radiolabeled Hedgehog Ligand for Targeted Nuclear Imaging of Breast Cancer (BC062737), J. Sims-Mourtada,  I. Tworowska,
    A. Azhdarinia, and H. Saso,  5th Era of Hope Meeting, DOD Breast Cancer Program, June 25th-28th,
  • 13th Annual Structural Biology Symposium, Seally Center for Structural Biology, UTMB, Galveston, TX, May18th-19th, (poster presentation)

2007

  • Symposium on Structural Biology in Cancer Research, Rice University, Houston, TX, Jan 11th.
  • Structural studies of the tRNAPhe anticodon stem-loop from Escherichia coli, Izabela Tworowska and Edward P. Nikonowicz,
  • 12th Annual Structural Biology Symposium, Seally Center for Structural Biology, UTMB, Galveston, TX, May18th-19th. 
  • 46th Annual Meeting of the Society of Toxicology, Charlotte, NC, March 25th-29th.
  • NMR  studies of the H/ACA box guide RNA from Euglena gracillis and its complex with target RNA, Izabela Tworowska and
  • Edward P. Nikonowicz,  12th Annual RNA Society Meeting, Madison-Wisconsin, WI, May 29th-June 3rd.   .
  • Individual and Cumulative Effects of Sequential Base Modifications in E. coli ACSLPhe, Izabela Tworowska and Edward P. Nikonowicz, Nucleic Acids Gordon Research Conference, Salve Regina University, Newport, RI, June 3rd-8th. 
  • 3rd Annual Symposium of the Institute of Biosciences and Bioengineering, Rice University, July 11th, Houston, TX., 
2006
  • Structural Studies of the H/ACA box guide RNA from Euglena gracilis, Izabela Tworowska, James Donarski and Edward P. Nikonowicz,16th Keck Center Annual Research Conference, Rice University, Houston, TX, October 13th.
  • NMR studies of the structure of the H/ACA box guide RNA from Euglena gracillis,  Izabela Tworowska, James Donarski and Edward P. Nikonowicz,2nd Southwest Regional Meeting ACS (SWRM), Houston, TX, October 19th-22nd.
  • Studies on the mechanism reaction of the E.coli  isopentenyl tRNA transferase (MiaA) with anticodon stem loop tRNAPhe (ACSL Phe), Izabela Tworowska and Edward P. Nikonowicz, XII International Conference on MagneticResonance in Biological Systems, Gottingen, Germany, August 20th-25th. 
  • Base Modification in RNA Structure and Function,Edward P Nikonowicz and Izabela Tworowska. 11th Annual Meeting of RNA Society, Seattle, Washington, June 20th-25th.
  • The mechanism of DMAPP: tRNA transferase (MiaA) from E. coli, Izabela Tworowska and Edward P. Nikonowicz.  Frontiers of NMR Spectroscopy, NMR Symposium, Cleveland Center for Structural Biology, Ohio, May 12th-14th. 
  • Accurate Measurement of 13C-13C and 15N-13C Residual Dipolar Couplings in Proteins and Nucleic Acids, Christopher P. Jaroniec, Tobias S. Ulmer, Jerome Boisbouvier, Izabela Tworowska, Edward P. Nikonowicz, Ad Bax.  47th ENC Experimental Nuclear Magnetic Resonance Conference,  The Asilomar Conference Center, Pacific Grove, California, April 23rd – 28th.
2005
  • Pseudouridine 32, 39-modified ACSL of E .coli tRNAPhe - the Watson-Crick or the bifurcated hydrogen bonds? , Izabela Tworowska and Edward P. Nikonowicz, The North Carolina RNA Society Symposium on RNA Biology VI: RNA, Tool and Target in North Carolina Biotechnology Center Research Triangle Park, October 21st-22nd.
  • Characterization metal-binding sites in the complex of Helix 21 of 16S rRNA and E.coli  ribosomal protein S8,  Izabela Tworowska, Marian Fabian, Daniel Jancura, Sean Moran and Edward P. Nikonowicz. Keck Center/ HAMB Annual Research Conference, Houston, TX October 6th-7th. 
  • 10th Annual Structural Biology Symposium. Seally Center for Structural Biology, UTMB, Galveston, TX.
  • Structural Studies of the Pseudouridine 32, 39-modified ACSL of E .coli tRNAPhe,  Izabela Tworowska and Edward P. Nikonowicz, 49th Biophysical Society Annual Meeting; Long Beach, CA, February 12th-16th. 

2004

  • 228th ACS National Meeting in Philadelphia, PA, August 22nd-26th. General Method of Pseudouridylation. The Substrate and Sequence Specificity of Pseudouridine Synthase (RluA). Izabela Tworowska and Edward P. Nikonowicz .
  • Keck Center Annual Research Conference October 8th. Unique Properties of Pseudouridine Synthase-RluA Structural Studies of the Double Modified Ψ32, Ψ39-ASCL from the E. coli tRNAPhe. Izabela Tworowska and Edward P. Nikonowicz.
  • 29th FEBS Congress, Warsaw, Poland, June 26th-July 1st. General method of Pseudouridylation of RNAs. Izabela Tworowska and Edward P. Nikonowicz.
  • Keystone Symposium, Frontiers in Structural Biology, Snowbird, Utah, April 13th-19th. General Method of Pseudouridylation and Structural Effect of Pseudouridine on RNA. Izabela Tworowska and Edward P. Nikonowicz.
  • Gordon Conference on Nucleic Acids, Salve Regina University, Newport, RI, June 6th-11th.
2003
  • The North Carolina RNA Society Symposium on RNA Biology, Research Triangle Center, October 17th-18th. Pseudouridylation - Why, where and how? Structure Prediction of the Modified Anticodon Stem-Loop of Escherichia coli tRNAPhe. Izabela Tworowska and Edward P. Nikonowicz.
  • 39th International Union Pure and Applied Chemistry (IUPAC) Congress, 86th Conference of the Canadian Society of Chemistry, Ottawa, Canada, 10th-15th August. Structure and dynamic of modified Anticodon Stem Loop of  E. coli tRNAPhe. Izabela Tworowska and Edward P. Nikonowicz.
  • 8th Annual Structural Biology Symposium, Sealy Center for Structural Biology, UTMB, Galveston, TX, May 2nd-4th. NMR Studies of the Modified Anticodon–Stem Loop of E. coli tRNAPhe. Izabela Tworowska and Edward P. Nikonowicz.

1998

  • XII International Round Table, Nucleosides, Nucleotides, and Their Biological Applications, Montpellier, France, September 6th-10th. 1) New Strategies for Chemical Synthesis of Oxosphorodithioates Derived from 3’- or 5’- thionucleosides. I.  Tworowska, W. Dabkowski. 2) New Phosphitylating Reagents Containing P-F Bond and Their Application in the Synthesis of P-F Nucleosidyl Phosphates, Thiophosphates and Selenophosphates. W.  Dabkowski, I. Tworowska, E. Poniatowska, J. Michalski and F. Cramer.
  • Nucleic Acids and Their Constituents, Chemical Evolution underlying Biological Evolution, Poznan, Poland, May 10th-13th. 1) Unconventional chemistry and stereochemistry of phosphorus compounds directed towards biophosphates and their structural analogues.  J. Michalski, W. Dabkowski, I. Tworowska; 2) New Strategies for Chemical Synthesis of Phosphorodithioates Derived from 3’- or 5’-Thionucleosides.W.  Dabkowski, I. Tworowska.

1997

  • Nucleic Acids and Related Macromolecules: Synthesis, Structure, Function and Applications, University of Ulm, Germany, September 4th-9th. Novel Unique Catalytic Activating Reagent in the Synthesis of Biophosphates via Phosphoamidite Route. W. Dabkowski, I. Tworowska, J. Michalski, F. Cramer

1995

  • Nucleic Acids Symposium, Leiden, Netherlands, August 6th-11th. Diastereoisomerically Pure Dinucleosidylphos-phorofluoridites and their Application in Stereospecific Synthesis of Dinucleosidylphosphorofluoridothionates. W. Dabkowski, I.Tworowska, J. Michalski, F. Kramer.
  • Polish Chemical Society Meeting, Lublin, Poland, September 25th-28th.

1994

  • Nucleosides, Nucleotides and Their Biological Applications, Leuven, Belgium, September 7th-11th. 1) Efficient Synthesis of 3’-Deoxynucleosidyl-N,N-Diisopropylamino Phosphorofluorides W. Dabkowski, I. Tworowska; 2) Sulfur Analogues of Nucleoside Phosphorofluoridates. New Structures of Potential Biological Importance. J. Michalski, W. Dabkowski, I. Tworowska, F. Cramer.
  • 3rd National Organic Chemistry Symposium, Warsaw, Poland, November 17th-19th.