Izabela Tworowska  Ph.D., M.S.Pharm.

                

          PATENTS
              

Compositions and methods for  the preparation of  kidney protective agents comprising amifostine  and amino acids   US Provisional Application  No 61/836,561

E. S. Delpassand, I. Tworowska, S. Thamake, D. Ranganathan

               Compositions, methods of synthesis and use of chelator-based monosccharide agents  GRANTED International Pub No PCT/US12/43255, 2010

               I. Tworowska, J. Sims-Mourtada, E.S. Delpassand

               Nanostructures comprising radiositopes and/or metals US Application No PCT/US2011/049119

               I. Tworowska (RadioMedix Inc), Y. Mackeyev, L. Wilson (Rice University)

               Compositions for Targeted Imaging and Therapy  GRANTED  US200858476, International Pub. No. WO/2008/119036)

               E.S. Delpassand, A. Azhdarinia, I. Tworowska, J. Sims-Mourtada 

               Radiolabeled Hedgehog derivatives for imaging and therapy  U.S. Application No. PCT/US09/35489, International Pub. No. WO/2009/108868),  

              J. Sims-Mourtada, A. Azhdarinia, I. Tworowska,  H. Saso  

PUBLICATIONS
Book
  • J. Michalski, W. Dabkowski and I. Tworowska, Phosphorus and Life Chemistry, Yufen Zhao (Ed.), 2005; Chapter 11, New Chemistry and Stereochemistry of Organophosphorus Compounds Directed Towards Biology, p. 233-255

Papers and abstracts
  • Hamiditabar M1, Ali M, Roys J, Wolin EM, OʼDorisio TM, Ranganathan D, Tworowska I, Strosberg JR, Delpassand ES. "Peptide Receptor Radionuclide Therapy With 177 Lu-Octreotate in Patients With Somatostatin Receptor Expressing Neuroendocrine Tumors: Six Years' Assessment", Clin Nucl Med., Mar 3 (2017)
  • D. Mueller, W. A P Breeman, I. Klette, M.l Gottschaldt, A. Odparlik, M. Baehre, I. Tworowska & M. K Schultz, “Radiolabeling of DOTA-like conjugated peptides with generator-produced 68Ga and using NaCl-based cationic elution method”, Nature Protocols, 2016, 11, 1057–1066, (2016).
  • I. Tworowska, D. Ranganathan, S. Thamake, E. Delpassand, A.  Mojtahedi,  M.  K. Schultz K.  Zhernosekov and  S. Marx; “Radiosynthesis of clinical doses of 68Ga-DOTATATE (GalioMedixTM) and validation of organic-matrix-based 68Ge/68Ga generators”; Nuc Med Biol, 2015 (online September 082515)
  • Mojtahedi, A. Alavi, S. Thamake, R. Amerinia, D. Ranganathan, I. Tworowska, E. S Delpassand “Assessment of vulnerable atherosclerotic and fibrotic plaques in coronary arteries using 68Ga-DOTATATE PET/CT”; Am J Nucl Med Mol Imaging 2015;5(1):65-71
  • Mojtahedi, S. Thamake, I. Tworowska, D. Ranganathan, and E. S Delpassand; “The value of 68Ga-DOTATATE PET/CT in diagnosis and management of neuroendocrine tumors compared to current FDA approved imaging modalities: a review of literature” Am J Nucl Med Mol Imaging. 2014; 4(5): 426–434.
  • M. K Schultz, P. Donahue, N. I Musgrave, K. Zhernosekov, C. Naidoo, A. Razbash, I.Tworowska, D. W Dick, G L. Watkins, M. M Graham, W. Runde, J. A Clanton, J. J Sunderland; “An Increasing Role for 68Ga PET Imaging: A Perspective on the Availability of Parent 68Ge Material for Generator Manufacturing in an Expanding Market”,  JAYPEE Journal, 2013, vol.47, no.1, 26-30
  • Detection of canonical hedgehog signaling in breast cancer by 131Iodine-labeled derivatives of the sonic hedgehog protein, J. Sim-Mourtada, D. Yang, I. Tworowska, R. Larson, D. Smith, N. Tsao, L. Opdenaker, F. Mourtada, and W.  Woodward,  Journal of Biomedicine and Biotechnology, May, 2012.
  • 68Ga-labeled click conjugate targeting GLUT1-transporters, Tworowska I.,  Zamanian S.,  Delpassand E., and Schultz M., J. Nucl.  Med. 2012; 53,  1568
  •  68Ga-labeled PSMA-targeting carbon nanotubes, Tworowska I., Ray S., Zamanian S., Delpassand E., Mackeyev Y., Wilson L., and Pomper M., J. Nucl. Med., 2012; 53: 1569
  • Characterization of organic matrix-based 68Ge/68Ga generators, Tworowska I., Zamanian S., and Delpassand E., J. Nucl. Med. 2012; 53: 1474.
  • One-pot radiolabeling and purification of tracers on solid-phase.  I. Tworowska, J. Sims-Mourtada, E. S. Delpassand, Bungoo Y., Pagel M.,    J. Nucl. Med. 2010; 51 (suppl. 2):376
  •  Carbon nanotubes modified with sonic-hedgehog ligand, I. Tworowska, J. Sims-Mourtada, D.Yang, F. Mourtada, E. Delpassand, Y. Mackeyev, L. Wilson,  J Nucl. Med., 2011, 52 (Supplement 1): 1479.
  • Application of click chemistry in the synthesis of 68Ga-labeled agents, I. Tworowska, J. Sims-Mourtada, E. Delpassand, J. Nucl. Med., 2011, 52 (Supplement 1): 1528.
  • Survival of patients with disseminated neuroendocrine tumors following multiple cycles of high activity 111In pentetreotide: Can pretreatment FDG status be a predictive factor?, R. Sharif, J. Sims-Mourtada, I. Tworowska, E. Delpassand, J. Nucl. Med.,2011, 52 (Supplement 1): 1312.
  • Hedgehog derivatives for tumor imaging. I. Tworowska, E. Delpassand, F. Mourtada, S. Ray, M. Pomper, and J. Sims-Mourtada,   J. Nucl. Med., 2010; 51 (suppl. 2): 484.       
  • Automated manufacturing of clinical-grade 177Lu- labeling DOTA0-Tyr3-octreotate using SmarTrace.  I.Tworowska, J. (Jim) Simon, J. Sims-Mourtada, F. Mourtada, and E. Delpassand,  J. Nucl. Med. 2010; 51(suppl.  2): 1551.  
  • Long-term evaluation of renal toxicity with multiple doses of high activity 111-In-pentetreotide in patients with disseminated neuroendocrine tumors.  R. Sharif, J. Sims-Mourtada, I. Tworowska, and E. Delpassand,  J. Nucl. Med.,  2010; 51(suppl. 2): 1158

  • Long-term survival and toxicity profile of patients with disseminated neuroendocrine tumors following multiple cycles of high activity 111In pentetreotide therapy.  E. S. Delpassand, R. Sharif, J. Sims-Mourtada, I. Tworowska, L. B. Anthony,  J. Clin. Oncol.,  28, 2010 (suppl; e13545)

  •  68Ga-glucosamine analogs for PET  imaging of cancer. I. Tworowska, H. Saso, J. Sims-Mourtada, F. Mourtada, E. Delpassand  and A. Azhdarinia,J. Nucl. Med., 2009. 
  •  Base pairing within the Ψ32Ψ39-modified anticodon arm of Escherichia coli tRNAPhe.  I. Tworowska  and  E. P.  Nikonowicz, J. Am. Chem. Soc., 2006,  128 (49), 15570 – 15571. full text  
  •  Accurate measurement of 15N- 13C residual dipolar couplings  in nucleic acids. Jaroniec CP, Boisbouvier J, Tworowska I,  Nikonowicz EP, Bax A,  J. Biomol. NMR., 2005, 31(3), 231-41. full text   
  • Highly selective O-phosphitylation of amino alcohols using P IIIreagents containing 4-nitro and 2,4-dinitroaryloxy leaving groups. W. Dabkowski, A. Ozarek and I. Tworowska , New Journal of Chemistry, 2005, (29), 1396-1399 full text
  • Synthesis of phosphorofluoridates and phosphorofluoridothioates via phosphoramidite approach. W. Dabkowski and I. Tworowska, Org. Biomol. Chemistry , 2005, 3, 866-874. full text
  • Metal Ion Stabilization of the U-turn of the A37 N6-dimethylally-Modified Anticodon Stem Loop of Escherichia coli tRNAPhe. J. Cabello-Villegas, I. Tworowska and E. P. Nikonowicz, Biochemistry, 2004, 43, 55-56. full text
  • The Phosphorofluoroamidite Aproach to Mixed Phosphites. I. Tworowska , W. Dabkowski and J. Michalski, J. Organometalic Chem., 2002, 643-644 , 490-493. full text
  • Synthesis of P-Fluorodithioacids of Phosphorus and their Synthetic Application. I. Tworowska , W. Dabkowski and J. Michalski, Phosphorus, Sulfur and Silicon , 2002, 177, 1855-1858. full text
  • Synthesis of Phosphorofluoridates and Phosphorofluoridothioates via the Phosphoramidite Approach. W. Dabkowski and I. Tworowska, J. Chem. Soc., Perkin Trans. 1 , 2001, 2462-2469. full text
  • Synthesis of Tri- and Tetracoordinate Phosphorus Compounds Containing the P-trifluoromethyl Group by Nucleophilic Trifluoromethylation of the Corresponding P-fluoro Systems. I. Tworowska , W. Dabkowski, and J. Michalski, Angew. Chem. Int. Ed., 2001 40(15) , 2898-2990. full text
  • New Efficient Synthesis of Thymidine Cyclic 3', 5'-Phosphorofluoridate and Its Sulfur Analogue via the Phosphoroamidite Route. W. Dabkowski, I. Tworowska, J. Michalski, F. Cramer, Nucleosides & Nucleotides, 2000 , 19 (10 &12), 1779-1785. full text
  • 2,4-Dinitrophenol: a Novel Activating Reagent in Nucleotide Synthesis via the Phosphoramidite Route. Design of New Effective Phosphitylating Reagents. W. Dabkowski, I. Tworowska , J. Michalski, F.Cramer, Tetrahedron Lett., 2000,41, 7535-7539. full text
  •  Novel Unique Activating Reagents in Synthesis of Biophosphates via Phosphoroamidite Route . W. Dabkowski, I. Tworowska, E. Poniatowska, J. Michalski, F. Cramer, Phosphorus, Sulfur and Silicon, 1999, 144-146, 109-112. full text
  • New Phosphitylating Reagents Containing P-F Bond and Their Application in the Synthesis of P-Fluoro Nucleosidyl Phosphates, Thiophosphates and Selenophosphates. W. Dabkowski, I. Tworowska, E. Poniatowska, J. Michalski, F. Cramer, Nucleosides & Nucleotides, 1999, 18(6,7), 1247-1248. full text
  • New strategies for chemical synthesis of phosphorodithioates from 2'- or 3'-or 5'-thionucleosides. W. Dabkowski, I. Tworowska , Nucleosides & Nucleotides, 1999 18(4,5), 977-988. full text
  • New Efficient Synthesis of Phosphorofluoridithioates RO-P(S)(S -)F and Their Structural Analogues. W. Dabkowski, I. Tworowska, J. Chem. Soc., Chem. Commun., 1998, 2611-2612. full text
  • A Simple and Efficient Synthesis of Nucleotide containing 5’-S- or 3’-S-phosphorothioate Linkage. W. Dabkowski, M. Michalska, I. Tworowska , Nucleosides & Nucleotides, 1998, 9-11, 1635-1637. full text
  • Novel Unique Catalytic Activating Reagents in the Synthesis of Biophosphates via the Phosphoramidite Route . W. Dabkowski, I. Tworowska, J. Michalski, F. Cramer, Nucleosides & Nucleotides, 1998, 9-11, 1639-1644. full text
  • Highly Efficient Synthesis of Phosphorodithioates Derived from 3’-Thiothymidine by Anhydro-ring Opening of 2,3’-Anhydro-5’-tritylthymidine with O,O-Disubstitued Phosphorothioic Acids. W. Dabkowski, M. Michalska, I. Tworowska, J. Chem. Soc., Chem. Commun.,1998, 427-428. full text
  • Trimethylchlorosilane: a novel activating reagent in nucleotide synthesis via the phosphoramidite route. W. Dabkowski, I. Tworowska, J. Michalski, F. Cramer, J. Chem. Soc., Chem. Commun.,1997, 877-878. full text
  • Nucleoside 3’-methylphosphonofluoridates and Nucleoside 3’-methylfluoridophos-phonothioates. New Convenient Intermediates in Large Scale Synthesis of Dinucleoside-(3’,5’)-methylphosphonates. W. Dabkowski, I. Tworowska , R. Saiakhov, Tetrahedron Lett., 1995, 36, 9223-9226. full text
  • First Synthesis of Nucleosidyl Phosphorofluoridothionates and a Convenient Synthesis of Nucleosidyl Phosphorofluoridates. W. Dabkowski, I. Tworowska, Chemistry Lett., 1995 (8), 727-728. full text
  • Synthesis of 2’-Deoxynucleosid-3’-yl-N,N-Diisopropylaminophosphorfluoridites. A New Class of Stable P(III) Nucleotides Containing a P-F Bond.  W. Dabkowski, I. Tworowska, Tetrahedron Lett., 1995, 36, 7, 1095-1098. full text
  • Diastereoisomerically Pure Dinucleosidylphosphorofluoridites and their Application in Stereospecific Synthesis of Dinucleosidylphosphorofluoridothionates. W. Dabkowski, I. Tworowska, J. Michalski, F. Cramer, J.Chem. Soc., Chem. Commun ., 1995, 1435-143  full text